Genetic characterization of acquired aplastic anemia by targeted sequencing

Genetic characterization of acquired aplastic anemia by targeted sequencing.

Acquired aplastic anemia.

In aplastic anemia, hematopoiesis fails: Blood cell counts are extremely low, and the bone marrow appears empty. The pathophysiology of aplastic anemia is now believed to be immune-mediated, with active destruction of blood-forming cells by lymphocytes. The aberrant immune response may be triggered by environmental exposures, such as to chemicals and drugs or viral infections and, perhaps, endo...

Aplastic Anemia - Diagnos tics and Therapy of Acquired Aplastic Anemia

Aplastic Anemia: Acquired and Inherited

Acquired aplastic anemia is a clinical syndrome in which there is a deficiency of red cells, neutrophils, monocytes, and platelets in the blood, and fatty replacement of the marrow with a near absence of hematopoietic precursor cells. Reticulocytopenia, neutropenia, monocytopenia, and thrombocytopenia, when severe, are life-threatening because of the risk of infection and bleeding, complicated ...

The epidemiology of acquired aplastic anemia.